Ontology-supported research on vaccine efficacy, safety and integrative biological networks

Integrating safety and efficacy evaluation throughout vaccine research and development.

Vaccines have led to some of the greatest public health achievements in history, including the worldwide eradication of naturally occurring smallpox and the near eradication of polio. In addition, vaccines have contributed to significant reduction in the disease burden imposed by measles, mumps, hepatitis, influenza, diphtheria, and many other infections. The science of vaccinology is dynamic; ...

ANTHRAX VACCINE Safety and Efficacy Issues

An integrative approach to modeling biological networks

Networks are used to model real-world phenomena in various domains, including systems biology. Since proteins carry out biological processes by interacting with other proteins, it is expected that cellular functions are reflected in the structure of protein-protein interaction (PPI) networks. Similarly, the topology of residue interaction graphs (RIGs) that model proteins' 3-dimensional structu...

An integrative approach to modelling biological networks

Since proteins carry out biological processes by interacting with other proteins, analyzing the structure of protein-protein interaction (PPI) networks could explain complex biological mechanisms, evolution, and disease. Similarly, studying protein structure networks, residue interaction graphs (RIGs), might provide insights into protein folding, stability, and function. The first step towards ...

Role of Psychological Factors on the Safety and Efficacy of the Coronavirus 2019 Vaccine (COVID-19): Letter to the Editor

Introduction: Coronavirus 2019 (COVID-19), as the biggest threat to public health in 2020, has caused many problems to people around the world during the current year. The COVID-19, which first appeared in Wuhan, China, was designated as acute respiratory syndrome 2 by the International Commission on Classification of Diseases World Health Organization and on March 11, 2020, it was introduced a...